| MMMidwestern Meat Locker LLC | Newell | SD | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| MMiller | Miller | SD | Food Manufacturing311119 | 1-19 | ◐ LIKELY ACTIVE |
| MMiller | Saint Lawrence | SD | Food Manufacturing311224 | 20-99 | ◐ LIKELY ACTIVE |
| MMiller | St. Lawrence | SD | Food Manufacturing311224 | 20-99 | ◐ LIKELY ACTIVE |
| MMitchell | Mitchell | SD | Food Manufacturing311224 | 20-99 | ◐ LIKELY ACTIVE |
| MSMitchell SD Truss | Mitchell | SD | Wood Product Manufacturing321215 | 20-99 | ◐ LIKELY ACTIVE |
| MIMiTek Inc. Britton | Britton | SD | Fabricated Metal Product Manufacturing332119 | 20-99 | ◐ LIKELY ACTIVE |
| MCMRBC Cidery | Custer | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| MDMsp Dak Precision Wall Britton | Britton | SD | Wood Product Manufacturing321992 | 1-19 | ◐ LIKELY ACTIVE |
| MDMsp Dak Truss Pros Britton | Britton | SD | Wood Product Manufacturing321215 | 20-99 | ◐ LIKELY ACTIVE |
| NLNevr Looz LLC | Sioux Falls | SD | Miscellaneous Manufacturing339920 | — | ◐ LIKELY ACTIVE |
| NSNorcraft - Sioux Falls | Sioux Falls | SD | Furniture and Related Product Manufacturing337110 | 100-499 | ◐ LIKELY ACTIVE |
| NVNorthfork Vineyard and Winery | Milbank | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| NSNorth Sioux City | North Sioux City | SD | Food Manufacturing311111 | 20-99 | ◐ LIKELY ACTIVE |
| NSNt Sales and Leasing, INC. | Watertown | SD | Machinery Manufacturing333310 | — | ◐ LIKELY ACTIVE |
| OFOrion Food Systems, LLC | Sioux Falls | SD | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| OHOVB HOLDINGS LLC DBA OVERBUILT and DBA EASIPOUR | Huron | SD | Machinery Manufacturing333120 | 20-99 | ◐ LIKELY ACTIVE |
| PMPanacea Meadery | Sioux Falls | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| PHParker Hannifin | Yankton | SD | Transportation Equipment Manufacturing336390 | 100-499 | ◐ LIKELY ACTIVE |
| PPPerformance Pet Products | Mitchell | SD | Food Manufacturing311111 | 20-99 | ◐ LIKELY ACTIVE |
| PLPete Lien & Sons Rapid City Central Mix | Rapid City | SD | Nonmetallic Mineral Product Manufacturing327320 | 1-19 | ◐ LIKELY ACTIVE |
| PMPFG Manufacturing OLM Food Systems Sioux Falls - 4040 | Sioux Falls | SD | Machinery Manufacturing333241 | 100-499 | ◐ LIKELY ACTIVE |
| PFPivotal Fab and Powder | Watertown | SD | Fabricated Metal Product Manufacturing332812 | 20-99 | ◐ LIKELY ACTIVE |
| PAPrairie AquaTech dba Houdek | Brookings | SD | Food Manufacturing311119 | 1-19 | ◐ LIKELY ACTIVE |
| PHPrairie Harvest Ltd | Spearfish | SD | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
Prince Manufacturing Corporation-North Sioux City Campus | North Sioux City | SD | Machinery Manufacturing333995 | 20-99 | ◐ LIKELY ACTIVE |
Prince Manufacturing Corporation-Yankton | Yankton | SD | Machinery Manufacturing333995 | 20-99 | ◐ LIKELY ACTIVE |
| PFProForm Fabrication, LLC | Beresford | SD | Machinery Manufacturing333241 | 20-99 | ◐ LIKELY ACTIVE |
| PDProSmiles Dental Studio Sioux Falls | Sioux Falls | SD | Miscellaneous Manufacturing339116 | 1-19 | ◐ LIKELY ACTIVE |
| PRProsperous Robotics Group, INC. | Sioux Falls | SD | Miscellaneous Manufacturing339113 | — | ◐ LIKELY ACTIVE |
| PDPro-Tec Division | Lennox | SD | Machinery Manufacturing333111 | 20-99 | ◐ LIKELY ACTIVE |
| PFProtech Fabrication and Machine LLC | Lake Norden | SD | Fabricated Metal Product Manufacturing332323 | — | ◐ LIKELY ACTIVE |
| QCQuality Custom Meats, LLC | Howard | SD | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| RRapcp | Rapid City | SD | Nonmetallic Mineral Product Manufacturing327332 | 20-99 | ◐ LIKELY ACTIVE |
| RCRapid City (1016) | Rapid City | SD | Nonmetallic Mineral Product Manufacturing327320 | 20-99 | ◐ LIKELY ACTIVE |
| RCRapid City, USA | Rapid City | SD | Computer and Electronic Product Manufacturing334511 | 20-99 | ◐ LIKELY ACTIVE |
| RHRaven HQ | Sioux Falls | SD | Computer and Electronic Product Manufacturing334513 | 100-499 | ◐ LIKELY ACTIVE |
| RMRaven Manufacturing | Sioux Falls | SD | Computer and Electronic Product Manufacturing334513 | 100-499 | ◐ LIKELY ACTIVE |
| RARed's All Natural, LLC. | North Sioux City | SD | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| RCRenner Corner Jerky | Renner | SD | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| RCRing Container Belle Fourche | Belle Fourche | SD | Plastics and Rubber Products Manufacturing326160 | 1-19 | ◐ LIKELY ACTIVE |
| RRoscoe | Roscoe | SD | Food Manufacturing311119 | 1-19 | ◐ LIKELY ACTIVE |
| RCRosebud Concrete, INC. | Winner | SD | Nonmetallic Mineral Product Manufacturing327320 | — | ◐ LIKELY ACTIVE |
| RVRott Vineyards, INC. | Jefferson | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| RRsd | N. Sioux City | SD | Food Manufacturing311111 | 100-499 | ◐ LIKELY ACTIVE |
| RLRs Logistics & Supply Company | Tea | SD | Electrical Equipment, Appliance & Component Manufacturing335999 | — | ◐ LIKELY ACTIVE |
| SFSchiltz Foods, Inc. | Sisseton | SD | Food Manufacturing311615 | — | ◐ LIKELY ACTIVE |
| SDSchlosser Ditching & Plumbing INC | Timber Lake | SD | Machinery Manufacturing333120 | — | ◐ LIKELY ACTIVE |
| SISchoch Industries LLC | Burbank | SD | Nonmetallic Mineral Product Manufacturing327390 | — | ◐ LIKELY ACTIVE |
| STSchuurmans, Terry | Avon | SD | Machinery Manufacturing333112 | — | ◐ LIKELY ACTIVE |