| SDSd02-dakt-south Dakota Sioux Falls | Sioux Falls | SD | Miscellaneous Manufacturing339950 | 100-499 | ◐ LIKELY ACTIVE |
SD Industries Mitchell | Mitchell | SD | Fabricated Metal Product Manufacturing332313 | 1-19 | ◐ LIKELY ACTIVE |
| SBSecond Breakfast Enterprises, LLC | Aurora | SD | Food Manufacturing311999 | — | ◐ LIKELY ACTIVE |
| SLSentry LLC Watertown | Watertown | SD | Transportation Equipment Manufacturing336214 | 100-499 | ◐ LIKELY ACTIVE |
| SCSimon - Custer Ready Mix | Custer | SD | Nonmetallic Mineral Product Manufacturing327320 | 1-19 | ◐ LIKELY ACTIVE |
| SHSimon Hot Springs Ready Mix | Hot Springs | SD | Nonmetallic Mineral Product Manufacturing327320 | 1-19 | ◐ LIKELY ACTIVE |
| SRSimon - Rapid City Concrete Plant | Rapid City | SD | Nonmetallic Mineral Product Manufacturing327320 | 1-19 | ◐ LIKELY ACTIVE |
| SFSioux Falls Admin Office | Sioux Falls | SD | Food Manufacturing311119 | 20-99 | ◐ LIKELY ACTIVE |
| SFSioux Falls Kitchen & Bath | Sioux Falls | SD | Furniture and Related Product Manufacturing337110 | 100-499 | ◐ LIKELY ACTIVE |
| SFSioux Falls Location | Sioux Falls | SD | Printing and Related Support Activities323111 | 20-99 | ◐ LIKELY ACTIVE |
| SFSioux Falls Regional Bakery - Main Store | Sioux Falls | SD | Food Manufacturing311812 | 20-99 | ◐ LIKELY ACTIVE |
| SSSioux Steel Livestock | Lennox | SD | Machinery Manufacturing333111 | 20-99 | ◐ LIKELY ACTIVE |
| SFSmithfield Foods | Sioux Falls | SD | Food Manufacturing311611 | 500+ | ◐ LIKELY ACTIVE |
| SGSolmax Geosynthetics,LLC | Spearfish | SD | Plastics and Rubber Products Manufacturing326113 | 1-19 | ◐ LIKELY ACTIVE |
| SDSouth Dakota | Brandon | SD | Miscellaneous Manufacturing339930 | 1-19 | ◐ LIKELY ACTIVE |
| SBSpartan - Brandon | Brandon | SD | Transportation Equipment Manufacturing336120 | 100-499 | ◐ LIKELY ACTIVE |
| SFSpartan Fire, LLC | Brandon | SD | Transportation Equipment Manufacturing336120 | — | ◐ LIKELY ACTIVE |
| SSSRAM - Spearfish | Spearfish | SD | Transportation Equipment Manufacturing336991 | 20-99 | ◐ LIKELY ACTIVE |
| SOStern Oil Company, INC | Freeman | SD | Petroleum and Coal Products Manufacturing324199 | — | ◐ LIKELY ACTIVE |
| S1Still 173, LLC | Vermillion | SD | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| SFStone Faces Winery | Hill City | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| SSStonemeadow Springs Winery | Custer | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| SWStrawbale Winery | Renner | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| SMSturgis Meats LLC | Sturgis | SD | Food Manufacturing311611 | — | ◐ LIKELY ACTIVE |
| SSSukup South Dakota Distribution Center | Watertown | SD | Machinery Manufacturing333111 | 1-19 | ◐ LIKELY ACTIVE |
| SSunbird | Huron | SD | Food Manufacturing311119 | 20-99 | ◐ LIKELY ACTIVE |
| SCSweetman Construction Company d/b/a Concrete Materials | Sioux Falls | SD | Nonmetallic Mineral Product Manufacturing327320 | 100-499 | ◐ LIKELY ACTIVE |
| TTTemperature Technology, INC. | Rapid City | SD | Computer and Electronic Product Manufacturing334512 | — | ◐ LIKELY ACTIVE |
| TBTerex Bidwell | Canton | SD | Machinery Manufacturing333120 | 20-99 | ◐ LIKELY ACTIVE |
| TCThe Cornerpost | Huron | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| TGThe Gardens Winery | Alcester | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| TMThe Meat House | Andover | SD | Food Manufacturing311611 | — | ◐ LIKELY ACTIVE |
| TRThe Rendezvous Point | Wilmot | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| TBThermoBond Buildings | Brandon | SD | Wood Product Manufacturing321992 | 100-499 | ◐ LIKELY ACTIVE |
| TVTimmerman Vineyards | Bridgewater | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| TCTRAIL-EZE Corsica | Corsica | SD | Transportation Equipment Manufacturing336212 | 1-19 | ◐ LIKELY ACTIVE |
| TPTRAIL-EZE Platte | Platte | SD | Transportation Equipment Manufacturing336212 | 1-19 | ◐ LIKELY ACTIVE |
| TDTriple D Marketing, INC | Sioux Falls | SD | Chemical Manufacturing325612 | — | ◐ LIKELY ACTIVE |
| TWTucker's Walk Vineyard | Garretson | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| UWUplifted Winery | Rapid City | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| VRValero Renewable Fuels Company, LLC dba Valero Aurora Plant | Aurora | SD | Chemical Manufacturing325193 | 20-99 | ◐ LIKELY ACTIVE |
| VDVan Dyke's Taxidermy | Woonsocket | SD | Nonmetallic Mineral Product Manufacturing327215 | 20-99 | ◐ LIKELY ACTIVE |
| VSVentis Surgical Solutions, INC | Dakota Dunes | SD | Miscellaneous Manufacturing339113 | — | ◐ LIKELY ACTIVE |
| VCVermeer Corporation - Freeman | Freeman | SD | Machinery Manufacturing333111 | 20-99 | ◐ LIKELY ACTIVE |
| VGVery Good Meat Company | Hudson | SD | Food Manufacturing311611 | — | ◐ LIKELY ACTIVE |
| VMViaflex - Madison | Madison | SD | Plastics and Rubber Products Manufacturing326113 | 20-99 | ◐ LIKELY ACTIVE |
| VVolga | Volga | SD | Food Manufacturing311224 | 100-499 | ◐ LIKELY ACTIVE |
| WMWall Meats Processing | Wall | SD | Food Manufacturing311611 | — | ◐ LIKELY ACTIVE |
| WMWall Meats Rapid | Rapid City | SD | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| WBWatertown Brewing Co. | Watertown | SD | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |