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Chemical Manufacturing

27,897 FACILITIESAll Census product lines →

NAICS 325

The Chemical Manufacturing industry, as defined by NAICS 325, had an annual payroll of about $110.1 billion according to the Bureau of Labor Statistics in 2025. The Bureau of Labor Statistics counted 25801 establishments in the Chemical Manufacturing industry across the United States in 2025. This register lists 27897 facilities in total.

SUMMARIZED FROM THE FEDERAL FIGURES ON THIS PAGE

Map, cities and product lines

Products made in this industry2,035 PRODUCTS

ProductSourceFacilities
Kit, Dna Detection, Human PapillomavirusFederal registry4
Kit, Identification, MycobacteriaFederal registry4
Kit, Serological, Positive ControlFederal registry4
Lavage, JetFederal registry4
Lipase-Esterase, Enzymatic, Photometric, LipaseFederal registry4
Lubricant, PatientFederal registry4
Material, ImpressionFederal registry4
Media, ElectroconductiveFederal registry4
Media, Mounting, Water SolubleFederal registry4
Mercuric Thiocyanate, Colorimetry, ChlorideFederal registry4
Micro PipetteFederal registry4
Mouthguard, PrescriptionFederal registry4
Nucleic Acid Detection System For Non-Viral Microorganism(S) Causing Sexually Transmitted InfectionsFederal registry4
Orthopedic Manual Surgical InstrumentFederal registry4
Parainfluenza Multiplex Nucleic Acid AssayFederal registry4
Photometric Method, Iron (Non-Heme)Federal registry4
Positioner, Tooth, PreformedFederal registry4
Products, Contact Lens Care, Rigid Gas PermeableFederal registry4
Protector, Skin PressureFederal registry4
Radioimmunoassay, 17-HydroxyprogesteroneFederal registry4
Radioimmunoassay, AldosteroneFederal registry4
Radioimmunoassay, CalcitoninFederal registry4
Radioimmunoassay, CortisolFederal registry4
Radioimmunoassay, EstroneFederal registry4
Radioimmunoassay, VancomycinFederal registry4
Resin, Root Canal FillingFederal registry4
Sealant, Pit And Fissure, And ConditionerFederal registry4
Sensor, Glucose, InvasiveFederal registry4
Single Use Only Blood Lancet With An Integral Sharps Injury Prevention FeatureFederal registry4
Sirius RedFederal registry4
Solution, Formalin-Sodium AcetateFederal registry4
Solution, Zenker'SFederal registry4
Somatic Gene Mutation Detection SystemFederal registry4
Sudan IiiFederal registry4
System, Imaging, Pulsed Echo, UltrasonicFederal registry4
System, Measurement, Blood-Pressure, Non-InvasiveFederal registry4
System, Perfusion, KidneyFederal registry4
System, Rebreathing, RadionuclideFederal registry4
System, Test, Beta-2-Microglobulin ImmunologicalFederal registry4
System, Test, Carcinoembryonic AntigenFederal registry4
System, Test, Low Density, LipoproteinFederal registry4
Test, Antigen, Nuclear, Epstein-Barr VirusFederal registry4
Test, Barbiturate, Employment And Insurance Testing, ExemptFederal registry4
Test, FibrinogenFederal registry4
Test, Methadone, Employment And Insurance Testing, ExemptFederal registry4
Test, Phencyclidine (Pcp), Over The CounterFederal registry4
Test, Prostate Specific Antigen, Free, (Noncomplexed) To Distinguish Prostate Cancer From Benign ConditionsFederal registry4
Test, Qualitative, For Hla, Non-DiagnosticFederal registry4
Test, Time, Partial ThromboplastinFederal registry4
Tube, Collection, Capillary BloodFederal registry4

Search all 27,897 facilities

Common questions

How many chemical manufacturing facilities are in the United States?

As of SEP 2026, FactoryRegistry lists 27,897 chemical manufacturing facilities (NAICS 325) across 55 states, compiled from EPA, OSHA and Census records.

Which state has the most chemical manufacturing facilities?

California, with 5,100 facilities listed.

How many chemical manufacturing facilities are still operating?

14,382 of the 27,897 listed carry a recent operating signal in federal data — the register's Active or Likely active status. The rest are listed from their filings alone, which is a gap in the federal record rather than evidence that a plant has closed.