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Chemical Manufacturing

27,897 FACILITIESAll Census product lines →

NAICS 325

The Chemical Manufacturing industry, as defined by NAICS 325, had an annual payroll of about $110.1 billion according to the Bureau of Labor Statistics in 2025. The Bureau of Labor Statistics counted 25801 establishments in the Chemical Manufacturing industry across the United States in 2025. This register lists 27897 facilities in total.

SUMMARIZED FROM THE FEDERAL FIGURES ON THIS PAGE

Map, cities and product lines

Products made in this industry2,035 PRODUCTS

ProductSourceFacilities
General Purpose ReagentFederal registry63
Single (Specified) Analyte Controls (Assayed And Unassayed)Federal registry45
Distilled spiritsFederal registry32
Multi-Analyte Controls, All Kinds (Assayed)Federal registry32
Reagents, Specific, AnalyteFederal registry29
Equipment, Laboratory, General Purpose, Labeled Or Promoted For A Specific Medical UseFederal registry24
Analyzer, Chemistry (Photometric, Discrete), For Clinical UseFederal registry22
Calibrator, SecondaryFederal registry22
Multi-Analyte Controls UnassayedFederal registry21
Calibrator, Multi-Analyte MixtureFederal registry19
Coronavirus Antigen Detection Test System.Federal registry18
Dressing, Wound, DrugFederal registry18
Reagent, Coronavirus SerologicalFederal registry18
Stains, MicrobiologicFederal registry18
Enzyme Immunoassay, AmphetamineFederal registry17
Enzyme Immunoassay, BarbiturateFederal registry17
Enzyme Immunoassay, CannabinoidsFederal registry17
Enzyme Immunoassay, OpiatesFederal registry17
Colorimeter, Photometer, Spectrophotometer For Clinical UseFederal registry16
Enzyme Immunoassay, BenzodiazepineFederal registry16
Enzyme Immunoassay, MethadoneFederal registry16
Enzyme Immunoassay, PhencyclidineFederal registry16
Lubricant, PersonalFederal registry16
Calibrator, PrimaryFederal registry15
Carbol FuchsinFederal registry15
Enzyme Immunoassay, Cocaine And Cocaine MetabolitesFederal registry15
Eosin YFederal registry15
Giemsa StainFederal registry15
Helicobacter PyloriFederal registry15
HematoxylinFederal registry15
Ph BufferFederal registry15
System, Test, Rheumatoid FactorFederal registry15
Tape And Bandage, AdhesiveFederal registry15
Formalin, Neutral BufferedFederal registry14
Glucose Oxidase, GlucoseFederal registry14
Nitroprusside, Ketones (Urinary, Non-Quant.)Federal registry14
Reagent, SchiffFederal registry14
Syringe, PistonFederal registry14
System, Test, Blood Glucose, Over The CounterFederal registry14
Visual, Pregnancy Hcg, Prescription UseFederal registry14
Calibrators, Drug SpecificFederal registry13
Container, Specimen Mailer And Storage, Non-SterileFederal registry13
Crystal Violet For HistologyFederal registry13
Disinfectant, Medical DevicesFederal registry13
Fixative, Alcohol ContainingFederal registry13
Products, Red-Cell Lysing ProductsFederal registry13
Reagent, Occult BloodFederal registry13
Reagents, 2019-Novel Coronavirus Nucleic AcidFederal registry13
System, Test, Vitamin DFederal registry13
Drug Mixture Control MaterialsFederal registry12

Search all 27,897 facilities

Common questions

How many chemical manufacturing facilities are in the United States?

As of SEP 2026, FactoryRegistry lists 27,897 chemical manufacturing facilities (NAICS 325) across 55 states, compiled from EPA, OSHA and Census records.

Which state has the most chemical manufacturing facilities?

California, with 5,100 facilities listed.

How many chemical manufacturing facilities are still operating?

14,382 of the 27,897 listed carry a recent operating signal in federal data — the register's Active or Likely active status. The rest are listed from their filings alone, which is a gap in the federal record rather than evidence that a plant has closed.