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Chemical Manufacturing

27,897 FACILITIESAll Census product lines →

NAICS 325

The Chemical Manufacturing industry, as defined by NAICS 325, had an annual payroll of about $110.1 billion according to the Bureau of Labor Statistics in 2025. The Bureau of Labor Statistics counted 25801 establishments in the Chemical Manufacturing industry across the United States in 2025. This register lists 27897 facilities in total.

SUMMARIZED FROM THE FEDERAL FIGURES ON THIS PAGE

Map, cities and product lines

Products made in this industry2,035 PRODUCTS

ProductSourceFacilities
Wax, Dental, IntraoralFederal registry4
Zika Virus Serological ReagentsFederal registry4
Abnormal Hemoglobin QuantitationFederal registry3
Accessories, CatheterFederal registry3
Accessory, Surgical ApparelFederal registry3
Acid, FuchsinFederal registry3
Acid, Hyaluronic, IntraarticularFederal registry3
Adhesive, Bracket And Tooth Conditioner, ResinFederal registry3
Adhesive, Denture, Polyvinyl Methylether Maleic Acid Calcium-Sodium Double SaltFederal registry3
AdhesivesCompany website3
Agent, Absorbable Hemostatic, Collagen BasedFederal registry3
Alpha-1 Microglobulin, Antigen, Antiserum, ControlFederal registry3
Alpha-2-Macroglobulin, Antigen, Antiserum, ControlFederal registry3
Anti-Dna Antibody, Antigen And ControlFederal registry3
Antigen, C. DifficileFederal registry3
Antigen, Cf (Including Cf Control), CytomegalovirusFederal registry3
Antigen, Inflammatory Response Marker, SepsisFederal registry3
Antigens, All Types, Escherichia ColiFederal registry3
Anti-Müllerian Hormone Test SystemFederal registry3
Antiserum, Cf, Epstein-Barr VirusFederal registry3
Apparatus, Suction, Single Patient Use, Portable, NonpoweredFederal registry3
Applicator, VaginalFederal registry3
ArthroscopeFederal registry3
Assayed Quality Control Material For Clinical Microbiology AssaysFederal registry3
Assay, Enzyme Linked Immunosorbent, Hepatitis C VirusFederal registry3
Assay, ErythropoietinFederal registry3
Atp And Creatine Kinase (Enzymatic), CreatineFederal registry3
Automated Antimicrobial Susceptibility Test System For Positive Blood Culture SamplesFederal registry3
Biosensor, Immunoassay, MyoglobinFederal registry3
Brilliant Cresyl BlueFederal registry3
Calibrator For Cell IndicesFederal registry3
Campylobacter Spp.Federal registry3
Cassettes, TissueFederal registry3
Catheter, PercutaneousFederal registry3
C. Difficile Nucleic Acid Amplification Test AssayFederal registry3
C. Difficile Toxin Gene Amplification AssayFederal registry3
Ceruloplasmin, Antigen, Antiserum, ControlFederal registry3
Chlamydophila Pneumoniae Dna Assay SystemFederal registry3
Citrulline, Arsenate, Nessler (Colorimetry), Ornithine Carbamyl TransferaseFederal registry3
Clamp, VascularFederal registry3
Colorimetric Method, Cpk Or IsoenzymesFederal registry3
Colorimetry, AcetaminophenFederal registry3
Colorimetry, SalicylateFederal registry3
Complement C1q, Antigen, Antiserum, ControlFederal registry3
Container, I.V.Federal registry3
Container, SharpsFederal registry3
Continuous Glucose Monitor Secondary DisplayFederal registry3
Control, Cell Counter, Normal And AbnormalFederal registry3
Control, Fecal Occult BloodFederal registry3
Controls For Blood-Gases, (Assayed And Unassayed)Federal registry3

Search all 27,897 facilities

Common questions

How many chemical manufacturing facilities are in the United States?

As of SEP 2026, FactoryRegistry lists 27,897 chemical manufacturing facilities (NAICS 325) across 55 states, compiled from EPA, OSHA and Census records.

Which state has the most chemical manufacturing facilities?

California, with 5,100 facilities listed.

How many chemical manufacturing facilities are still operating?

14,382 of the 27,897 listed carry a recent operating signal in federal data — the register's Active or Likely active status. The rest are listed from their filings alone, which is a gap in the federal record rather than evidence that a plant has closed.