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Chemical Manufacturing

27,897 FACILITIESAll Census product lines →

NAICS 325

The Chemical Manufacturing industry, as defined by NAICS 325, had an annual payroll of about $110.1 billion according to the Bureau of Labor Statistics in 2025. The Bureau of Labor Statistics counted 25801 establishments in the Chemical Manufacturing industry across the United States in 2025. This register lists 27897 facilities in total.

SUMMARIZED FROM THE FEDERAL FIGURES ON THIS PAGE

Map, cities and product lines

Products made in this industry2,035 PRODUCTS

ProductSourceFacilities
Next Generation Sequencing Oncology Panel, Somatic Or Germline Variant Detection SystemFederal registry3
Non-Sars Coronavirus Multiplex Nucleic Acid AssayFederal registry3
Nucleic Acid Amplification Assay System, Group B Streptococcus, Direct Specimen TestFederal registry3
Oil Red OFederal registry3
Oral Wound DressingFederal registry3
Pack, Hot Or Cold, ReusableFederal registry3
Pad, Heating, PoweredFederal registry3
Panels, Test, Susceptibility, AntimicrobialFederal registry3
Paper, Obstetric PhFederal registry3
Patch, Pledget And Intracardiac, Petp, Ptfe, PolypropyleneFederal registry3
Plaque Disclosing AgentFederal registry3
Plasma, Coagulation Factor DeficientFederal registry3
Platelet Counting, ManualFederal registry3
Point Of Care Hiv Serology Diagnostic And/Or Supplemental TestFederal registry3
Polymer Patient Examination GloveFederal registry3
Powered Laser Surgical InstrumentFederal registry3
P-Toluenesulphonyl-L-Arginine Methyl Ester (U.V.), TrypsinFederal registry3
Pump, Infusion, InsulinFederal registry3
Radioimmunoassay, C-Peptides Of ProinsulinFederal registry3
Radioimmunoassay, Immunoglobulins (G, A, M)Federal registry3
Radioimmunoassay, PregnenoloneFederal registry3
Radioimmunoassay, Thyroxine-Binding GlobulinFederal registry3
Reagent, Leishmanii SerologicalFederal registry3
Reagents, Monkeypox Virus Nucleic Acid.Federal registry3
Reagents, Test, TetrahydrocannabinolFederal registry3
Regulator, Pressure, Gas CylinderFederal registry3
Respiratory Specimen Nucleic Acid Sars-Cov-2 TestFederal registry3
RetractorFederal registry3
Romanowsky StainsFederal registry3
Sealant, PolymerizingFederal registry3
Sensor, Glucose, Invasive, Non-Adjunctive, Factory-Calibrated, User-InitiatedFederal registry3
Sera, Animal And HumanFederal registry3
Set, Perfusion, Kidney, DisposableFederal registry3
Shield, Eye, Ophthalmic (Including Sunlamp Protective Eyewear And Post-Mydriatic Eyewear)Federal registry3
Silver NitrateFederal registry3
Simple Point-Of-Care Device To Directly Detect Sars-Cov-2 Viral Targets From Clinical Specimens In Near-Patient SettingsFederal registry3
Sirolimus Test SystemFederal registry3
Solution, Copper Sulfate For Specific Gravity DeterminationsFederal registry3
Solution, Orth'SFederal registry3
Source, Brachytherapy, RadionuclideFederal registry3
Staple, ImplantableFederal registry3
Sterilization Wrap Containers, Trays, Cassettes & Other AccessoriesFederal registry3
Subsystem, Water PurificationFederal registry3
Supplies, Blood-BankFederal registry3
Suture, Nonabsorbable, Synthetic, PolyethyleneFederal registry3
System/Device, Pharmacy CompoundingFederal registry3
System, Fibrinogen DeterminationFederal registry3
System, Processing For Frozen BloodFederal registry3
System, Test, Automated Blood Grouping And AntibodyFederal registry3
Tape, Measuring, Rulers And CalipersFederal registry3

Search all 27,897 facilities

Common questions

How many chemical manufacturing facilities are in the United States?

As of SEP 2026, FactoryRegistry lists 27,897 chemical manufacturing facilities (NAICS 325) across 55 states, compiled from EPA, OSHA and Census records.

Which state has the most chemical manufacturing facilities?

California, with 5,100 facilities listed.

How many chemical manufacturing facilities are still operating?

14,382 of the 27,897 listed carry a recent operating signal in federal data — the register's Active or Likely active status. The rest are listed from their filings alone, which is a gap in the federal record rather than evidence that a plant has closed.