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Chemical Manufacturing

27,897 FACILITIESAll Census product lines →

NAICS 325

The Chemical Manufacturing industry, as defined by NAICS 325, had an annual payroll of about $110.1 billion according to the Bureau of Labor Statistics in 2025. The Bureau of Labor Statistics counted 25801 establishments in the Chemical Manufacturing industry across the United States in 2025. This register lists 27897 facilities in total.

SUMMARIZED FROM THE FEDERAL FIGURES ON THIS PAGE

Map, cities and product lines
Map of United States manufacturing facilities

Products made in this industry2,035 PRODUCTS

ProductSourceFacilities
Phantom, Flood Source, NuclearFederal registry2
Phantom, Test-Pattern, RadionuclideFederal registry2
Ph Rate Measurement, Carbon-DioxideFederal registry2
Plasma, Coagulase, Human, Horse And RabbitFederal registry2
Plate, Base, ShellacFederal registry2
Plates And Equipment, Radial ImmunodiffusionFederal registry2
Plug, PunctumFederal registry2
Pneumocystis CariniiFederal registry2
Polyethylene Glycol (Carbowax)Federal registry2
Powder, PorcelainFederal registry2
Powered Microneedle DeviceFederal registry2
Prealbumin, Fitc, Antigen, Antiserum, ControlFederal registry2
PrepregCompany website2
PrimersCompany website2
Probe, Uptake, NuclearFederal registry2
Processor, Cervical Cytology Slide, AutomatedFederal registry2
Protein, Complement, Antigen, Antiserum, ControlFederal registry2
Pump, Infusion, ElastomericFederal registry2
Pump, Infusion, Insulin, To Be Used With Invasive Glucose SensorFederal registry2
Qualitative Cytomegalovirus Nucleic Acid-Based Detection Device For Congenital Cytomegalovirus InfectionFederal registry2
Quality Control Material, Genetics, DnaFederal registry2
Radioassay, Intrinsic Factor Blocking AntibodyFederal registry2
Radioimmunoassay, Cholyglycine, Bile AcidsFederal registry2
Radioimmunoassay, MethaqualoneFederal registry2
Radioimmunoassay, Total Estrogens, NonpregnancyFederal registry2
Reader, Cervical Cytology Slide, AutomatedFederal registry2
Reagent/Device, Inoculum CalibrationFederal registry2
Reagents, Antibody, Legionella, Direct & Indirect FluorescentFederal registry2
Reagents, CysticercosisFederal registry2
Reagents, Ebola Zaire Virus (Detected In The West Africa Outbreak In 2014) Nucleic AcidFederal registry2
Reagents, Zika Virus Nucleic AcidFederal registry2
Research Use Only/Immunology DevicesFederal registry2
Respirator, SurgicalFederal registry2
Respiratory Syncytial Virus, Antigen, Antibody, IfaFederal registry2
Retainer, Screw Expansion, OrthodonticFederal registry2
Retractor, All TypesFederal registry2
Rt-Qpcr Assay For Mrna Transcript Immune BiomarkersFederal registry2
S-316 SolventCompany website2
Saccharogenic, AmylaseFederal registry2
Scaler, UltrasonicFederal registry2
Scalpel, One-PieceFederal registry2
Scissors, Medical, DisposableFederal registry2
Semen Analysis DeviceFederal registry2
Set, Administration, For Peritoneal Dialysis, DisposableFederal registry2
Shaker/StirrerFederal registry2
Sound, UterineFederal registry2
Source, Calibration, Sealed, NuclearFederal registry2
Spatula, Cervical, CytologicalFederal registry2
Specialty ProductsCompany website2
Speculum, EntFederal registry2

Search all 27,897 facilities

Common questions

How many chemical manufacturing facilities are in the United States?

As of SEP 2026, FactoryRegistry lists 27,897 chemical manufacturing facilities (NAICS 325) across 55 states, compiled from EPA, OSHA and Census records.

Which state has the most chemical manufacturing facilities?

California, with 5,100 facilities listed.

How many chemical manufacturing facilities are still operating?

14,382 of the 27,897 listed carry a recent operating signal in federal data — the register's Active or Likely active status. The rest are listed from their filings alone, which is a gap in the federal record rather than evidence that a plant has closed.