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Chemical Manufacturing

27,897 FACILITIESAll Census product lines →

NAICS 325

The Chemical Manufacturing industry, as defined by NAICS 325, had an annual payroll of about $110.1 billion according to the Bureau of Labor Statistics in 2025. The Bureau of Labor Statistics counted 25801 establishments in the Chemical Manufacturing industry across the United States in 2025. This register lists 27897 facilities in total.

SUMMARIZED FROM THE FEDERAL FIGURES ON THIS PAGE

Map, cities and product lines

Products made in this industry2,035 PRODUCTS

ProductSourceFacilities
Test, Urine LeukocyteFederal registry10
Aniline BlueFederal registry9
Antigens, All Groups, Streptococcus Spp.Federal registry9
Blood, Occult, Colorimetric, In UrineFederal registry9
Counter, Cell, Automated (Particle Counter)Federal registry9
C-Reactive Protein, Antigen, Antiserum, And ControlFederal registry9
Culture Media, Non-Propagating TransportFederal registry9
Culture Media, Selective And Non-DifferentialFederal registry9
DetergentFederal registry9
Devices Detecting Influenza A, B, And C Virus AntigensFederal registry9
Diazo Colorimetry, BilirubinFederal registry9
Discs, Strips And Reagents, Microorganism DifferentiationFederal registry9
Electrode, Ion-Specific, ChlorideFederal registry9
Enzyme Linked Immunoabsorption Assay, Treponema PallidumFederal registry9
Extractable Antinuclear Antibody, Antigen And ControlFederal registry9
Fiber, Medical, AbsorbentFederal registry9
Gas, Laser GeneratingFederal registry9
Glucose Dehydrogenase, GlucoseFederal registry9
Kit, Test, Pregnancy, Hcg, Over The CounterFederal registry9
Mounting MediaFederal registry9
Needle, Hypodermic, Single LumenFederal registry9
Plasma, Coagulation ControlFederal registry9
Quality Control SlidesFederal registry9
Radioimmunoassay, Luteinizing HormoneFederal registry9
Radioimmunoassay, ProgesteroneFederal registry9
Radioimmunoassay, Thyroid-Stimulating HormoneFederal registry9
Saliva, ArtificialFederal registry9
Slides, MicroscopeFederal registry9
Syringe, Irrigating (Non Dental)Federal registry9
System, Test, C-Reactive ProteinFederal registry9
System, Test, Human Chorionic GonadotropinFederal registry9
System, Test, Infectious MononucleosisFederal registry9
Test, Opiates, Over The CounterFederal registry9
Test System, Antineutrophil Cytoplasmic Antibodies (Anca)Federal registry9
Transferrin, Antigen, Antiserum, ControlFederal registry9
Agent, ClearingFederal registry8
Basic FuchsinFederal registry8
Cleaner, Ultrasonic, Medical InstrumentFederal registry8
Dressing, Wound, HydrophilicFederal registry8
Drug Specific Control MaterialsFederal registry8
Enzymatic, Carbon-DioxideFederal registry8
Enzyme Linked Immunoabsorbent Assay, CytomegalovirusFederal registry8
Enzyme Linked Immunoabsorbent Assay, RubellaFederal registry8
Enzyme Linked Immunoabsorbent Assay, Toxoplasma GondiiFederal registry8
Enzyme Linked Immunosorbent Assay, Herpes Simplex Virus, Hsv-1Federal registry8
Fibrinogen And Fibrin Split Products, Antigen, Antiserum, ControlFederal registry8
Material, Impression Tray, ResinFederal registry8
Media And Components, Synthetic Cell And Tissue CultureFederal registry8
Multi-Target Respiratory Specimen Nucleic Acid Test Including Sars-Cov-2 And Other Microbial AgentsFederal registry8
Nasal Spray, Ent DeliveryFederal registry8

Search all 27,897 facilities

Common questions

How many chemical manufacturing facilities are in the United States?

As of SEP 2026, FactoryRegistry lists 27,897 chemical manufacturing facilities (NAICS 325) across 55 states, compiled from EPA, OSHA and Census records.

Which state has the most chemical manufacturing facilities?

California, with 5,100 facilities listed.

How many chemical manufacturing facilities are still operating?

14,382 of the 27,897 listed carry a recent operating signal in federal data — the register's Active or Likely active status. The rest are listed from their filings alone, which is a gap in the federal record rather than evidence that a plant has closed.