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Chemical Manufacturing

27,897 FACILITIESAll Census product lines →

NAICS 325

The Chemical Manufacturing industry, as defined by NAICS 325, had an annual payroll of about $110.1 billion according to the Bureau of Labor Statistics in 2025. The Bureau of Labor Statistics counted 25801 establishments in the Chemical Manufacturing industry across the United States in 2025. This register lists 27897 facilities in total.

SUMMARIZED FROM THE FEDERAL FIGURES ON THIS PAGE

Map, cities and product lines

Products made in this industry2,035 PRODUCTS

ProductSourceFacilities
Over-The-Counter Covid-19 Antigen TestFederal registry8
Radioimmunoassay, EstradiolFederal registry8
Radioimmunoassay, Prolactin (Lactogen)Federal registry8
Radioimmunoassay, Total TriiodothyronineFederal registry8
Refractometer For Clinical UseFederal registry8
Set, I.V. Fluid TransferFederal registry8
Solution, IsotonicFederal registry8
Thin Layer Chromatography, MethamphetamineFederal registry8
Toluidine BlueFederal registry8
Varnish, CavityFederal registry8
Wound Dressing With Animal-Derived Material(S)Federal registry8
Acid, Ascorbic, 2,4-Dinitrophenylhydrazine (Spectrophotometric)Federal registry7
Acid, Lactic, Enzymatic MethodFederal registry7
Agent, Polishing, Abrasive, Oral CavityFederal registry7
Alcian BlueFederal registry7
Alcohol Dehydrogenase, Specific Reagent For Ethanol Enzyme MethodFederal registry7
Antimitochondrial Antibody, Indirect Immunofluorescent, Antigen, ControlFederal registry7
Antinuclear Antibody, Antigen, ControlFederal registry7
Bandage, LiquidFederal registry7
Bandage, Liquid, Skin ProtectantFederal registry7
Bordetella Pertussis Dna Assay SystemFederal registry7
Container, Specimen, SterileFederal registry7
Crown And Bridge, Temporary, ResinFederal registry7
Culture Media, EnrichedFederal registry7
Culture Media, General Nutrient BrothFederal registry7
Culture Media, Selective And DifferentialFederal registry7
Electrode, Ion Specific, CalciumFederal registry7
Electrode Measurement, Blood-Gases (Pco2, Po2) And Blood PhFederal registry7
Enzyme Controls (Assayed And Unassayed)Federal registry7
Ferritin, Antigen, Antiserum, ControlFederal registry7
Filler, Bone Void, Calcium CompoundFederal registry7
Fixative, Formalin-ContainingFederal registry7
Gold ChlorideFederal registry7
Hexokinase, GlucoseFederal registry7
Ige, Antigen, Antiserum, ControlFederal registry7
Kit, Quality Control For Blood Banking ReagentsFederal registry7
Legionella, Spp., ElisaFederal registry7
Lipoprotein, Low-Density, Antigen, Antiserum, ControlFederal registry7
Material, Tooth Shade, ResinFederal registry7
Myoglobin, Antigen, Antiserum, ControlFederal registry7
Nadh Oxidation/Nad Reduction, Ast/SgotFederal registry7
Phosphomolybdate (Colorimetric), Inorganic PhosphorusFederal registry7
Preservative, CytologicalFederal registry7
Prostate-Specific Antigen (Psa) For Management Of Prostate CancersFederal registry7
Radioimmunoassay, AndrostenedioneFederal registry7
Radioimmunoassay, Follicle-Stimulating HormoneFederal registry7
Radioimmunoassay, Parathyroid HormoneFederal registry7
Resin, Denture, Relining, Repairing, RebasingFederal registry7
Stain, ReticulocyteFederal registry7
Sterilant, Medical DevicesFederal registry7

Search all 27,897 facilities

Common questions

How many chemical manufacturing facilities are in the United States?

As of SEP 2026, FactoryRegistry lists 27,897 chemical manufacturing facilities (NAICS 325) across 55 states, compiled from EPA, OSHA and Census records.

Which state has the most chemical manufacturing facilities?

California, with 5,100 facilities listed.

How many chemical manufacturing facilities are still operating?

14,382 of the 27,897 listed carry a recent operating signal in federal data — the register's Active or Likely active status. The rest are listed from their filings alone, which is a gap in the federal record rather than evidence that a plant has closed.