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Chemical Manufacturing

27,897 FACILITIESAll Census product lines →

NAICS 325

The Chemical Manufacturing industry, as defined by NAICS 325, had an annual payroll of about $110.1 billion according to the Bureau of Labor Statistics in 2025. The Bureau of Labor Statistics counted 25801 establishments in the Chemical Manufacturing industry across the United States in 2025. This register lists 27897 facilities in total.

SUMMARIZED FROM THE FEDERAL FIGURES ON THIS PAGE

Map, cities and product lines

Products made in this industry2,035 PRODUCTS

ProductSourceFacilities
Nad Reduction/Nadh Oxidation, Lactate DehydrogenaseFederal registry6
Nebulizer (Direct Patient Interface)Federal registry6
Nuclear Fast RedFederal registry6
Orange GFederal registry6
Photometric Method, MagnesiumFederal registry6
Plasmodium Spp. Detection ReagentsFederal registry6
Prealbumin, Antigen, Antiserum, ControlFederal registry6
Radioassay, Triiodothyronine UptakeFederal registry6
Radioassay, Vitamin B12Federal registry6
Radioimmunoassay, Dehydroepiandrosterone (Free And Sulfate)Federal registry6
Radioimmunoassay, Immunoreactive InsulinFederal registry6
Reagent, Borrelia Serological ReagentFederal registry6
Solution, Formalin-Alcohol-Acetic AcidFederal registry6
Solution, Lugol'SFederal registry6
Stains, Chemical SolutionFederal registry6
Stains, Dye PowderFederal registry6
Supplement, Culture MediaFederal registry6
System, Test, Automated, Antimicrobial Susceptibility, Short IncubationFederal registry6
System, Test, Thyroid AutoantibodyFederal registry6
Test, Epithelial Ovarian Tumor-Associated Antigen (Ca125)Federal registry6
Test, Hiv DetectionFederal registry6
Test, Natriuretic PeptideFederal registry6
Toothbrush, ManualFederal registry6
Tubes, Vials, Systems, Serum Separators, Blood CollectionFederal registry6
Turbidimetric Method, Protein Or Albumin (Urinary, Non-Quant.)Federal registry6
Urease And Glutamic Dehydrogenase, Urea NitrogenFederal registry6
Accessories, Cleaning Brushes, For EndoscopeFederal registry5
Accessories, Implant, Dental, EndosseousFederal registry5
Acridine OrangeFederal registry5
Alcohol Control MaterialsFederal registry5
Antibodies, GliadinFederal registry5
Antibody Igm, If, Epstein-Barr VirusFederal registry5
Anti-Dna Indirect Immunofluorescent Solid PhaseFederal registry5
Antigen, Cf (Including Cf Controls), Respiratory Syncytial VirusFederal registry5
Antigens, Nontreponemal, AllFederal registry5
Automated Indirect Immunofluorescence Microscope And Software-Assisted System For Clinical UseFederal registry5
Azo Dye, CalciumFederal registry5
Bandage, ElasticFederal registry5
Biebrich ScarletFederal registry5
Biuret (Colorimetric), Total ProteinFederal registry5
Bromcresol Green Dye-Binding, AlbuminFederal registry5
Bromcresol Purple Dye-Binding, AlbuminFederal registry5
Calibrator For Platelet CountingFederal registry5
Calibrators, Drug MixtureFederal registry5
Calibrators, Ethyl AlcoholFederal registry5
Catalytic Methods, AmylaseFederal registry5
CoatingsCompany website5
Colorimetric Method, TriglyceridesFederal registry5
Complement C3, Antigen, Antiserum, ControlFederal registry5
Complement C4, Antigen, Antiserum, ControlFederal registry5

Search all 27,897 facilities

Common questions

How many chemical manufacturing facilities are in the United States?

As of SEP 2026, FactoryRegistry lists 27,897 chemical manufacturing facilities (NAICS 325) across 55 states, compiled from EPA, OSHA and Census records.

Which state has the most chemical manufacturing facilities?

California, with 5,100 facilities listed.

How many chemical manufacturing facilities are still operating?

14,382 of the 27,897 listed carry a recent operating signal in federal data — the register's Active or Likely active status. The rest are listed from their filings alone, which is a gap in the federal record rather than evidence that a plant has closed.