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Chemical Manufacturing

27,897 FACILITIESAll Census product lines →

NAICS 325

The Chemical Manufacturing industry, as defined by NAICS 325, had an annual payroll of about $110.1 billion according to the Bureau of Labor Statistics in 2025. The Bureau of Labor Statistics counted 25801 establishments in the Chemical Manufacturing industry across the United States in 2025. This register lists 27897 facilities in total.

SUMMARIZED FROM THE FEDERAL FIGURES ON THIS PAGE

Map, cities and product lines

Products made in this industry2,035 PRODUCTS

ProductSourceFacilities
Continuous Measurement ThermometerFederal registry5
Control, HemoglobinFederal registry5
Culture Media, Single Biochemical TestFederal registry5
CytocentrifugeFederal registry5
Device, General Purpose, Microbiology, DiagnosticFederal registry5
Devices, Measure, Antibodies To Glomerular Basement Membrane (Gbm)Federal registry5
Device, Specimen CollectionFederal registry5
Dispenser, Liquid MedicationFederal registry5
Dressing, Wound, OcclusiveFederal registry5
Elastomer, Silicone, For Scar ManagementFederal registry5
Enzymatic Method, AmmoniaFederal registry5
Enzyme Immunoassay, Nicotine And Nicotine MetabolitesFederal registry5
Enzyme Linked Immunoabsorbent Assay, Mycoplasma Spp.Federal registry5
Fast GreenFederal registry5
Ferrozine (Colorimetric) Iron Binding CapacityFederal registry5
Fibrin Split ProductsFederal registry5
Filters, Cell Collection, Tissue ProcessingFederal registry5
Fixative, Metallic ContainingFederal registry5
Flow Cytometric Reagents And Accessories.Federal registry5
Formulations, Balanced Salt SolutionsFederal registry5
Gastrointestinal Pathogen Panel Multiplex Nucleic Acid-Based Assay SystemFederal registry5
Human Metapneumovirus (Hmpv) Rna Assay SystemFederal registry5
Integrated Continuous Glucose Monitoring System, Factory CalibratedFederal registry5
Introducer, Syringe NeedleFederal registry5
Kinetic Method, Gamma-Glutamyl TranspeptidaseFederal registry5
Light GreenFederal registry5
Medical Device Data SystemFederal registry5
Multiple Use Blood Lancet For Single Patient Use OnlyFederal registry5
Mycoplasma Pneumoniae Dna Assay SystemFederal registry5
Nad Reduction/Nadh Oxidation, Cpk Or IsoenzymesFederal registry5
Nephelometer, For Clinical UseFederal registry5
Nitrophenylphosphate, Alkaline Phosphatase Or IsoenzymesFederal registry5
Pack, Hot Or Cold, DisposableFederal registry5
Plasma, Control, NormalFederal registry5
Pump, InfusionFederal registry5
Radioimmunoassay, ActhFederal registry5
Radioimmunoassay, EstriolFederal registry5
Radioimmunoassay, Free ThyroxineFederal registry5
Radioimmunoassay, Human Growth HormoneFederal registry5
Radioimmunoassay (Two-Site Solid Phase), FerritinFederal registry5
Reagent, Rickettsia SerologicalFederal registry5
Reagents, Clostridium Difficile ToxinFederal registry5
Reagents For Molecular Diagnostic Test SystemsFederal registry5
Single Use Only Blood Lancet Without An Integral Sharps Injury Prevention FeatureFederal registry5
Solution, Carnoy'SFederal registry5
Stain, Trichrome, Mallory'SFederal registry5
System, Blood CulturingFederal registry5
System, Multipurpose For In Vitro Coagulation StudiesFederal registry5
System,Test,Antibodies,B2 - Glycoprotein I (B2 - Gpi)Federal registry5
System, Test, Carbohydrate Antigen (Ca19-9), For Monitoring And Management Of Pancreatic CancerFederal registry5

Search all 27,897 facilities

Common questions

How many chemical manufacturing facilities are in the United States?

As of SEP 2026, FactoryRegistry lists 27,897 chemical manufacturing facilities (NAICS 325) across 55 states, compiled from EPA, OSHA and Census records.

Which state has the most chemical manufacturing facilities?

California, with 5,100 facilities listed.

How many chemical manufacturing facilities are still operating?

14,382 of the 27,897 listed carry a recent operating signal in federal data — the register's Active or Likely active status. The rest are listed from their filings alone, which is a gap in the federal record rather than evidence that a plant has closed.