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Chemical Manufacturing

27,897 FACILITIESAll Census product lines →

NAICS 325

The Chemical Manufacturing industry, as defined by NAICS 325, had an annual payroll of about $110.1 billion according to the Bureau of Labor Statistics in 2025. The Bureau of Labor Statistics counted 25801 establishments in the Chemical Manufacturing industry across the United States in 2025. This register lists 27897 facilities in total.

SUMMARIZED FROM THE FEDERAL FIGURES ON THIS PAGE

Map, cities and product lines

Products made in this industry2,035 PRODUCTS

ProductSourceFacilities
Colorimetric Method, Gamma-Glutamyl TranspeptidaseFederal registry4
Colorimetry, CholinesteraseFederal registry4
Congo RedFederal registry4
Container, EmbeddingFederal registry4
Container, Specimen Mailer And Storage, SterileFederal registry4
Continuous Glucose Monitor Retrospective Data Analysis SoftwareFederal registry4
Control, Plasma, AbnormalFederal registry4
Control, White-CellFederal registry4
Covid-19 Multi-Analyte Antigen DeviceFederal registry4
Cresolphthalein Complexone, CalciumFederal registry4
Culture Media, Antimicrobial Susceptibility Test, Excluding Mueller Hinton AgarFederal registry4
Culture Media, Antimicrobial Susceptibility Test, Mueller Hinton Agar/BrothFederal registry4
Culture Media, For Isolation Of Pathogenic NeisseriaFederal registry4
Culture Media, Multiple Biochemical TestFederal registry4
CyclosporineFederal registry4
Dam, RubberFederal registry4
Dengue Serological ReagentsFederal registry4
Dermal Cooling Pack/Vacuum/MassagerFederal registry4
Device, Automated Sedimentation RateFederal registry4
Dialysate Concentrate For Hemodialysis (Liquid Or Powder)Federal registry4
Dna-Reagents, NeisseriaFederal registry4
Drape, Surgical, ExemptFederal registry4
Dressing, Wound And Burn, Hydrogel W/Drug And/Or BiologicFederal registry4
Electrophoretic Separation, Alkaline Phosphatase IsoenzymesFederal registry4
Enzyme Immunoassay, GentamicinFederal registry4
Enzyme Immunoassay, PhenobarbitalFederal registry4
Enzyme Immunoassay, TheophyllineFederal registry4
Enzyme Linked Immunoabsorbent Assay, Herpes Simplex Virus, Non-SpecificFederal registry4
Enzyme Linked Immunoabsorbent Assay, RotavirusFederal registry4
Enzyme Linked Immunoabsorbent Assay, Varicella-ZosterFederal registry4
Floss, DentalFederal registry4
Fluid, Diluting, Red-CellFederal registry4
Fluid, Diluting, White-CellFederal registry4
Fluorometric Method, Cpk Or IsoenzymesFederal registry4
ForcepsFederal registry4
Gauze / Sponge,Nonresorbable For External UseFederal registry4
Giardia Spp.Federal registry4
Glucose-6-Phosphate Dehydrogenase (Erythrocytic), ScreeningFederal registry4
Groups A, C And G Beta-Hemolytic Streptococcus Nucleic Acid Amplification SystemFederal registry4
Hemoglobin A1c Test SystemFederal registry4
Herpes Virus (Vzv, Hsv1, Hsv2), Dna Detection Assay For Cutaneous And Mucocutaneous Lesion SamplesFederal registry4
Iga, Antigen, Antiserum, ControlFederal registry4
Igm, Antigen, Antiserum, ControlFederal registry4
Immunohistochemistry Antibody Assay, Estrogen ReceptorFederal registry4
Immunohistochemistry Assay, Antibody, Progesterone ReceptorFederal registry4
Indirect Bonding TrayFederal registry4
Instrument, Hematocrit, AutomatedFederal registry4
Instrument, Surgical, DisposableFederal registry4
Integrated Continuous Glucose Monitoring System, Factory Calibrated, Not For Use With Automated Insulin Delivery SystemsFederal registry4
Kit, Direct Antigen, Positive ControlFederal registry4

Search all 27,897 facilities

Common questions

How many chemical manufacturing facilities are in the United States?

As of SEP 2026, FactoryRegistry lists 27,897 chemical manufacturing facilities (NAICS 325) across 55 states, compiled from EPA, OSHA and Census records.

Which state has the most chemical manufacturing facilities?

California, with 5,100 facilities listed.

How many chemical manufacturing facilities are still operating?

14,382 of the 27,897 listed carry a recent operating signal in federal data — the register's Active or Likely active status. The rest are listed from their filings alone, which is a gap in the federal record rather than evidence that a plant has closed.