| RRRecens Respiratio, INC | Roanoke, VA | Miscellaneous Manufacturing339112 | — | ◐ LIKELY ACTIVE |
| RRoanoke | Daleville, VA | Machinery Manufacturing333120 | 500+ | ◐ LIKELY ACTIVE |
| RRoanoke | Roanoke, VA | Wood Product Manufacturing321920 | 20–99 | ◐ LIKELY ACTIVE |
| RBRoanoke Branch 52 | Roanoke, VA | Chemical Manufacturing325120 | 1–19 | ◐ LIKELY ACTIVE |
| RIRoanoke IG | Vinton, VA | Nonmetallic Mineral Product Manufacturing327215 | 100–499 | ◐ LIKELY ACTIVE |
| RPRoanoke Plant | Roanoke, VA | Nonmetallic Mineral Product Manufacturing327320 | 20–99 | ◐ LIKELY ACTIVE |
| RVRoanoke, Va | Roanoke, VA | Paper Manufacturing322211 | 100–499 | ◐ LIKELY ACTIVE |
| RVRoanoke Va Bakery | Roanoke, VA | Food Manufacturing311812 | 100–499 | ◐ LIKELY ACTIVE |
| RVRoanoke VA Recycling | Roanoke, VA | Transportation Equipment Manufacturing336510 | 1–19 | ◐ LIKELY ACTIVE |
| RMRocky Mount | Rocky Mount, VA | Wood Product Manufacturing321991 | 100–499 | ◐ LIKELY ACTIVE |
| RRRoosters Rise -n- Shine Distillery, LLC | Moneta, VA | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| SBSalem Branch | Salem, VA | Food Manufacturing311520 | 20–99 | ◐ LIKELY ACTIVE |
| SNSAL Novonesis | Salem, VA | Chemical Manufacturing325414 | 20–99 | ◐ LIKELY ACTIVE |
| SRSEMCO Roanoke | Roanoke, VA | Fabricated Metal Product Manufacturing332322 | 20–99 | ◐ LIKELY ACTIVE |
| SMShenandoah Machine & Maintenance CO | Roanoke, VA | Fabricated Metal Product Manufacturing332710 | — | ◐ LIKELY ACTIVE |
| SDSteel Dynamics Roanoke Bar Division | Roanoke, VA | Primary Metal Manufacturing331110 | 100–499 | ◐ LIKELY ACTIVE |
| TNThree Notchd Distilling Company | Roanoke, VA | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| TCTwin Creeks Distillery, INC. | Rocky Mount, VA | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| VVVinapple Valley Vineyard | Bent Mountain, VA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| VMVirginia Mountain Vineyards | Fincastle, VA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| VBVoyant Beauty Roanoke | Roanoke, VA | Chemical Manufacturing325620 | 100–499 | ◐ LIKELY ACTIVE |
| WCWebster C. Hall Vineyards, LLC | Callaway, VA | Beverage and Tobacco Product Manufacturing312130 | — | ◐ LIKELY ACTIVE |
| W1Wpax 1025 (roanoke, Va - F) | Roanoke, VA | Transportation Equipment Manufacturing336211 | 20–99 | ◐ LIKELY ACTIVE |
| W4WPAX 4077 - (Cloverdale - F) | Cloverdale, VA | Transportation Equipment Manufacturing336211 | 100–499 | ◐ LIKELY ACTIVE |
| YLY2o, LLC | Roanoke, VA | Chemical Manufacturing325180 | — | ◐ LIKELY ACTIVE |
| FRFarhana & Rod Arts, INC. | Fincastle, VA | Textile Product Mills314110 | — | ◐ LIKELY ACTIVE |
| ACAdams Construction CO - Blue Ridge Asphalt Plant | Blue Ridge, VA | Petroleum and Coal Products Manufacturing324121 | — | ◇ UNVERIFIED |
| ACAdams Construction Co-jacks Mountain Asphalt Plant | Rocky Mount, VA | Petroleum and Coal Products Manufacturing324121 | — | ◇ UNVERIFIED |
| ACAdams Construction CO - Rockydale Asphalt Plant | Roanoke, VA | Petroleum and Coal Products Manufacturing324121 | — | ◇ UNVERIFIED |
| ASAlien Silkscreen LLC | Salem, VA | Printing and Related Support Activities323113 | — | ◇ UNVERIFIED |
| ASAl Steel Fabricators | Roanoke, VA | Fabricated Metal Product Manufacturing332312 | — | ◇ UNVERIFIED |
| ADAmerican Door and Glass Sw Va, INC. | Roanoke, VA | Fabricated Metal Product Manufacturing332321 | — | ◇ UNVERIFIED |
| AGArdagh Group | Roanoke, VA | Fabricated Metal Product Manufacturing332431 | — | ◇ UNVERIFIED |
| APArrington Paving Company, Inc. | Rocky Mount, VA | Petroleum and Coal Products Manufacturing324121 | — | ◇ UNVERIFIED |
| ACAtlas Copco Secoroc LLC | Roanoke, VA | Machinery Manufacturing333131 | — | ◇ UNVERIFIED |
| ANAzko Nobel Coatings INC. | Roanoke, VA | Chemical Manufacturing325510 | — | ◇ UNVERIFIED |
| BCBatech Corporation | Roanoke, VA | Chemical Manufacturing325991 | — | ◇ UNVERIFIED |
| BBentech | Roanoke, VA | Fabricated Metal Product Manufacturing332710 | — | ◇ UNVERIFIED |
| BBBlack Bear CORP. | Roanoke, VA | Chemical Manufacturing325611 | — | ◇ UNVERIFIED |
| BRBlue Ridge Fabricators, INC. | Roanoke, VA | Fabricated Metal Product Manufacturing332312 | — | ◇ UNVERIFIED |
| BRBlue Ridge Sign & Stamp Inc | Roanoke, VA | Miscellaneous Manufacturing339950 | — | ◇ UNVERIFIED |
| BSBolling Steel Co., INC. | Salem, VA | Fabricated Metal Product Manufacturing332312 | — | ◇ UNVERIFIED |
| BSBoxley Salem Asphalt Plant | Salem, VA | Petroleum and Coal Products Manufacturing324121 | — | ◇ UNVERIFIED |
| BSBuck Simmons Vault Service, INC | Roanoke, VA | Nonmetallic Mineral Product Manufacturing327390 | — | ◇ UNVERIFIED |
| BSBudget Signs | Roanoke, VA | Miscellaneous Manufacturing339950 | — | ◇ UNVERIFIED |
| CLCcsr, LLC | Roanoke, VA | Furniture and Related Product Manufacturing337110 | — | ◇ UNVERIFIED |
| CCCentury Control Systems, INC. | Roanoke, VA | Computer and Electronic Product Manufacturing334510 | — | ◇ UNVERIFIED |
| CYCesium Yarn LLC | Roanoke, VA | Furniture and Related Product Manufacturing337121 | — | ◇ UNVERIFIED |
| CConrock | Roanoke, VA | Nonmetallic Mineral Product Manufacturing327331 | — | ◇ UNVERIFIED |
| CConvertagraphics | Roanoke, VA | Printing and Related Support Activities323110 | — | ◇ UNVERIFIED |