| SWSmith & Wesson INC | Springfield, MA | Leather and Allied Product Manufacturing316999 | 500+ | ◐ LIKELY ACTIVE |
| SLSolenis LLC | Chicopee, MA | Chemical Manufacturing325211 | 20–99 | ◐ LIKELY ACTIVE |
| AMApmar Metal Finishing | Springfield, MA | Fabricated Metal Product Manufacturing332813 | — | ◐ LIKELY ACTIVE |
Belt Technologies, INC. | Agawam, MA | Fabricated Metal Product Manufacturing332999 | — | ◐ LIKELY ACTIVE |
| BOBern Optics INC | Westfield, MA | Machinery Manufacturing333314 | 20–99 | ◐ LIKELY ACTIVE |
| CECartamundi East Longmeadow LLC | East Longmeadow, MA | Paper Manufacturing322299 | 100–499 | ◐ LIKELY ACTIVE |
| CPChicopee Provision Company | Chicopee, MA | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| CMCrrc Ma - Springfield | Springfield, MA | Transportation Equipment Manufacturing336510 | 100–499 | ◐ LIKELY ACTIVE |
| DPDuc Pac Corporation the | Springfield, MA | Fabricated Metal Product Manufacturing332322 | 20–99 | ◐ LIKELY ACTIVE |
| FPFountain Plating Co, LLC | West Springfield, MA | Fabricated Metal Product Manufacturing332812 | 100–499 | ◐ LIKELY ACTIVE |
| HCHeatbath CORP | Indian Orchard, MA | Chemical Manufacturing325998 | — | ◐ LIKELY ACTIVE |
| IIIrwin Industrial Tool Company | East Longmeadow, MA | Primary Metal Manufacturing331222 | 20–99 | ◐ LIKELY ACTIVE |
| MPMcnairn Packaging | Westfield, MA | Paper Manufacturing322121 | 100–499 | ◐ LIKELY ACTIVE |
| MAMicro Abrasives CORP | Westfield, MA | Nonmetallic Mineral Product Manufacturing327910 | 20–99 | ◐ LIKELY ACTIVE |
| SASealed Air CORP | Holyoke, MA | Paper Manufacturing322221 | 20–99 | ◐ LIKELY ACTIVE |
| SPSmithfield Packaged Meats CORP Spfld | Springfield, MA | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| SISolutia INC - Indian Orchard Plant | Springfield, MA | Chemical Manufacturing325199 | — | ◐ LIKELY ACTIVE |
| TPToner Plastics | East Longmeadow, MA | Plastics and Rubber Products Manufacturing326199 | 20–99 | ◐ LIKELY ACTIVE |
| VAVision American Saw LLC | East Longmeadow, MA | Fabricated Metal Product Manufacturing332213 | — | ◐ LIKELY ACTIVE |
| WBWestern Bronze INC | West Springfield, MA | Primary Metal Manufacturing331522 | — | ◐ LIKELY ACTIVE |
| WFWestside Finishing CO INC | Holyoke, MA | Fabricated Metal Product Manufacturing332812 | 20–99 | ◐ LIKELY ACTIVE |
| IMInternational Metal Products | Chicopee, MA | Fabricated Metal Product Manufacturing332116 | — | ◐ LIKELY ACTIVE |
| JAJain Americas - Nucedar Mills | Chicopee, MA | Chemical Manufacturing325211 | — | ◐ LIKELY ACTIVE |
| SFStorms Forge Incorporated | Springfield, City of, MA | Fabricated Metal Product Manufacturing332111 | — | ◐ LIKELY ACTIVE |
| TMTrelleborg Monson | Monson, MA | Textile Mills313320 | — | ◐ LIKELY ACTIVE |
| TTurbocare | Chicopee, MA | Fabricated Metal Product Manufacturing332999 | — | ◐ LIKELY ACTIVE |
| UTUS Tsubaki Automotive Division Manufacturing Plant | Chicopee, MA | Fabricated Metal Product Manufacturing332111 | — | ◐ LIKELY ACTIVE |
| ACAstro Chemicals | Springfield, MA | Chemical Manufacturing325110 | — | ◇ UNVERIFIED |
| CCChicopee Concrete Services INC | Chicopee, MA | Nonmetallic Mineral Product Manufacturing327320 | — | ◇ UNVERIFIED |
Construction Services | Wilbraham, MA | Nonmetallic Mineral Product Manufacturing327320 | — | ◇ UNVERIFIED |
| CCovidien | Chicopee, MA | Paper Manufacturing322221 | — | ◇ UNVERIFIED |
| JAJames Austin Company | Ludlow, MA | Chemical Manufacturing325188 | — | ◇ UNVERIFIED |
| LPLuster-on Products INC | Springfield, MA | Chemical Manufacturing325199 | — | ◇ UNVERIFIED |
| OIOmg INC | Agawam, MA | Fabricated Metal Product Manufacturing332722 | — | ◇ UNVERIFIED |
| RPRandolph Products CO | Chicopee, MA | Chemical Manufacturing325510 | — | ◇ UNVERIFIED |
| RWRpm Wood Finishes Group INC | Westfield, MA | Chemical Manufacturing325510 | — | ◇ UNVERIFIED |
Sonoco Products CO | Holyoke, MA | Paper Manufacturing322130 | — | ◇ UNVERIFIED |
| UTU.s. Tsubaki Power Transmission LLC - Roller Chain Division | Holyoke, MA | Fabricated Metal Product Manufacturing332618 | — | ◇ UNVERIFIED |
| AMAdvance Mfg.co., INC. | Westfield, MA | Fabricated Metal Product Manufacturing332710 | 100–499 | ▲ REPORTED CLOSED |
Ft Custom Printing & Embroidery Apparel LLC | Ludlow, MA | Printing and Related Support Activities323111 | — | ◐ LIKELY ACTIVE |
| MPMillennium Press | Agawam, MA | Printing and Related Support Activities323110 | — | ◐ LIKELY ACTIVE |
Orthotics & Prosthetics Laboratories, INC. | Springfield, MA | Miscellaneous Manufacturing339113 | — | ◐ LIKELY ACTIVE |
Oss Print Lab, LLC | Westfield, MA | Printing and Related Support Activities323113 | — | ◐ LIKELY ACTIVE |
Terra Americana, LLC | Southwick, MA | Food Manufacturing311999 | — | ◐ LIKELY ACTIVE |
Transcon Technologies, LLC | Westfield, MA | Computer and Electronic Product Manufacturing334416 | — | ◐ LIKELY ACTIVE |
| AAAdvanced Aerostructures INC | Chicopee, MA | Fabricated Metal Product Manufacturing332813 | — | ◐ LIKELY ACTIVE |
| PPPackage Printing CO | West Springfield, MA | Printing and Related Support Activities323110 | — | ◐ LIKELY ACTIVE |
| AFAtlas Founders INC | Agawam, MA | Primary Metal Manufacturing331522 | — | ◇ UNVERIFIED |
| MPMansir Printing LLC | Holyoke, MA | Printing and Related Support Activities323110 | — | ◇ UNVERIFIED |
| ADAdvanced Drainage System | Ludlow, MA | Chemical Manufacturing325211 | — | ◐ LIKELY ACTIVE |