| TLTerex Load King Div | Elk Point | SD | Transportation Equipment Manufacturing336211 | — | ◐ LIKELY ACTIVE |
| TKTrail King Inds INC | Mitchell | SD | Transportation Equipment Manufacturing336212 | — | ◐ LIKELY ACTIVE |
Twin City Die Castings CO - Watertown Div | Watertown | SD | Primary Metal Manufacturing331522 | — | ◐ LIKELY ACTIVE |
| TCTwin City Fan Companies LTD Dba Tcf Aerovent CO. | Aberdeen | SD | Machinery Manufacturing333412 | — | ◐ LIKELY ACTIVE |
| TCTwin City Fan Cos Brookings | Brookings | SD | Machinery Manufacturing333412 | — | ◐ LIKELY ACTIVE |
| WCWalling Chemical Company | Sioux Falls | SD | Chemical Manufacturing325998 | — | ◐ LIKELY ACTIVE |
Wheeler Lumber L.l.c. | Whitewood | SD | Wood Product Manufacturing321114 | — | ◐ LIKELY ACTIVE |
| WTWilson Trailer Company | Yankton | SD | Transportation Equipment Manufacturing336212 | — | ◐ LIKELY ACTIVE |
| DCDegeest Corporation | Tea | SD | Fabricated Metal Product Manufacturing332312 | 20-99 | ◇ UNVERIFIED |
Raven Industries INC. (applied Technologies) | Sioux Falls | SD | Computer and Electronic Product Manufacturing334418 | — | ◇ UNVERIFIED |
| TLThe Lankota Group | Huron | SD | Machinery Manufacturing333111 | 20-99 | ◇ UNVERIFIED |
| AAA & a Engraving INC | Rapid City | SD | Fabricated Metal Product Manufacturing332813 | 20-99 | ◐ LIKELY ACTIVE |
| AMAviation Manufacturing Group, LLC DBA The Freeman Company | Yankton | SD | Transportation Equipment Manufacturing336413 | 20-99 | ◐ LIKELY ACTIVE |
| BPBrookings-sd-falcon Plastics | Brookings | SD | Miscellaneous Manufacturing339113 | 1-19 | ◐ LIKELY ACTIVE |
| CICardinal Industries, INC. | Aberdeen | SD | Plastics and Rubber Products Manufacturing326199 | — | ▲ REPORTED CLOSED |
| DFDakota Foundry, INC. | Webster | SD | Primary Metal Manufacturing331511 | 20-99 | ◐ LIKELY ACTIVE |
| ETEmpirical Technology | Dakota Dunes | SD | Food Manufacturing311611 | 500+ | ◐ LIKELY ACTIVE |
| JEJerry's Electric, INC | Colman | SD | Electrical Equipment, Appliance & Component Manufacturing335311 | 20-99 | ◐ LIKELY ACTIVE |
| JDJr Distributing INC | Lake Norden | SD | Food Manufacturing311119 | 20-99 | ◐ LIKELY ACTIVE |
| MMMds Manufacturing | Parkston | SD | Fabricated Metal Product Manufacturing332212 | 20-99 | ◐ LIKELY ACTIVE |
| NNNovita Nutrition, LLC | Brookings | SD | Food Manufacturing311119 | 20-99 | ◐ LIKELY ACTIVE |
| PCPowdertech Corporation | Webster | SD | Fabricated Metal Product Manufacturing332812 | — | ◐ LIKELY ACTIVE |
| PSPreform Solutions, INC. | Sioux Falls | SD | Plastics and Rubber Products Manufacturing326160 | 20-99 | ◐ LIKELY ACTIVE |
Sd Industries | Alexandria | SD | Primary Metal Manufacturing331210 | 20-99 | ◐ LIKELY ACTIVE |
| SWSupreme Welding, INC. | Clear Lake | SD | Fabricated Metal Product Manufacturing332312 | 1-19 | ◐ LIKELY ACTIVE |
| WSWatertown SD | Watertown | SD | Primary Metal Manufacturing331523 | 20-99 | ◐ LIKELY ACTIVE |
| DFDakota Fiberglass INC | Webster | SD | Plastics and Rubber Products Manufacturing326199 | 1-19 | ◐ LIKELY ACTIVE |
| GAGcp Applied Technologies INC. @ Gage Brothers | Sioux Falls | SD | Nonmetallic Mineral Product Manufacturing327390 | 100-499 | ◐ LIKELY ACTIVE |
| TRT & R Service Company | Colman | SD | Electrical Equipment, Appliance & Component Manufacturing335311 | 1-19 | ◐ LIKELY ACTIVE |
| ACAshley's Cabinets | Sioux Falls | SD | Furniture and Related Product Manufacturing337110 | 20-99 | ◇ UNVERIFIED |
| APAsphalt Paving & Materials | Huron | SD | Petroleum and Coal Products Manufacturing324121 | 1-19 | ◇ UNVERIFIED |
| BEBanner Engineering | Aberdeen | SD | Computer and Electronic Product Manufacturing334111 | — | ◇ UNVERIFIED |
| BBBimbo Bakeries | Sioux Falls | SD | Food Manufacturing311812 | — | ◇ UNVERIFIED |
| CPCentral Plains Industries | Clark | SD | Machinery Manufacturing333111 | 20-99 | ◇ UNVERIFIED |
| CDConcrete Dakota Redi Mix INC. | Watertown | SD | Nonmetallic Mineral Product Manufacturing327390 | 1-19 | ◇ UNVERIFIED |
| CICounterpart, INC | Brookings | SD | Fabricated Metal Product Manufacturing332322 | 20-99 | ◇ UNVERIFIED |
| DIDonnerite INC. | Howard | SD | Plastics and Rubber Products Manufacturing326199 | 1-19 | ◇ UNVERIFIED |
| KMK-w Manufacturing | Sioux Falls | SD | Machinery Manufacturing333111 | — | ◇ UNVERIFIED |
| LMLucid Manufacturing Incorporated (former) | Mitchell | SD | Wood Product Manufacturing321999 | — | ◇ UNVERIFIED |
| MLMetrix, LLC | Watertown | SD | Fabricated Metal Product Manufacturing332812 | 20-99 | ◇ UNVERIFIED |
| MRMidwest Ready Mix | Vermillion | SD | Nonmetallic Mineral Product Manufacturing327320 | 1-19 | ◇ UNVERIFIED |
| OOverbuilt | Huron | SD | Machinery Manufacturing333120 | — | ◇ UNVERIFIED |
| UCUnited Concrete | Harrisburg | SD | Nonmetallic Mineral Product Manufacturing327320 | 20-99 | ◇ UNVERIFIED |
| WIWinter, INC. | Sioux Falls | SD | Nonmetallic Mineral Product Manufacturing327390 | 20-99 | ◇ UNVERIFIED |
| ARAce Ready Mix- Sioux Falls | Sioux Falls | SD | Nonmetallic Mineral Product Manufacturing327320 | 20-99 | ◐ LIKELY ACTIVE |
| BDBadlands Distillery LLC | Kadoka | SD | Beverage and Tobacco Product Manufacturing312140 | 1-19 | ◐ LIKELY ACTIVE |
| BTBaker Timber Products Inc. | Rapid City | SD | Wood Product Manufacturing321113 | 20-99 | ◐ LIKELY ACTIVE |
| BBBel Brands USA | Brookings | SD | Food Manufacturing311513 | 100-499 | ◐ LIKELY ACTIVE |
| BFBenchmark Foam (former) | Watertown | SD | Plastics and Rubber Products Manufacturing326140 | — | ◐ LIKELY ACTIVE |
| BHBlack Hills Ammunition INC | Rapid City | SD | Fabricated Metal Product Manufacturing332992 | — | ◐ LIKELY ACTIVE |