| HEHydro Extrusion Usa, LLC | Yankton | SD | Primary Metal Manufacturing331314 | — | ◐ LIKELY ACTIVE |
| ISIdic Specialty Drilling Chemicals LLC | Belle Fourche | SD | Chemical Manufacturing325998 | — | ◐ LIKELY ACTIVE |
| JEJerry's Electric, INC | Colman | SD | Electrical Equipment, Appliance & Component Manufacturing335311 | — | ◐ LIKELY ACTIVE |
| KRKnife River | Parkston, City of | SD | Nonmetallic Mineral Product Manufacturing327320 | — | ◐ LIKELY ACTIVE |
| LLLanast LLC Dba Arctic Ice | North Sioux City | SD | Beverage and Tobacco Product Manufacturing312113 | — | ◐ LIKELY ACTIVE |
| LSLyle Signs INC | De Smet | SD | Fabricated Metal Product Manufacturing332999 | — | ◐ LIKELY ACTIVE |
| MMMajestic Medical LLC | Harrisburg | SD | Miscellaneous Manufacturing339113 | — | ◐ LIKELY ACTIVE |
| MMMds Manufacturing | Parkston | SD | Fabricated Metal Product Manufacturing332212 | — | ◐ LIKELY ACTIVE |
| MIMidcom INC | Aberdeen | SD | Computer and Electronic Product Manufacturing334416 | — | ◐ LIKELY ACTIVE |
| PMPetersen Machine, LLC | Brandon | SD | Fabricated Metal Product Manufacturing332710 | — | ◐ LIKELY ACTIVE |
| PAPrairie AquaTech Manufacturing, LLC dba Houdek Manufacturing | Volga | SD | Food Manufacturing311119 | 20-99 | ◐ LIKELY ACTIVE |
| PBPremier Bee LLC | Sioux Falls | SD | Wood Product Manufacturing321999 | 20-99 | ◐ LIKELY ACTIVE |
| PCPresidio Components INC | Sioux Falls | SD | Computer and Electronic Product Manufacturing334416 | — | ◐ LIKELY ACTIVE |
| RBRidley Block Operations - Whitewood | Whitewood | SD | Food Manufacturing311119 | 20-99 | ◐ LIKELY ACTIVE |
| SIScherer Inc. | Sioux Falls | SD | Fabricated Metal Product Manufacturing332710 | 20-99 | ◐ LIKELY ACTIVE |
| SDSd Dot - Glacial Lakes Rest Area | Aberdeen | SD | Petroleum and Coal Products Manufacturing324121 | — | ◐ LIKELY ACTIVE |
Sd Industries | Alexandria | SD | Primary Metal Manufacturing331210 | 20-99 | ◐ LIKELY ACTIVE |
| SSSioux Steel Company | Lennox | SD | Fabricated Metal Product Manufacturing332311 | 20-99 | ◐ LIKELY ACTIVE |
| SSSioux Steel Livestock Division | Lennox | SD | Fabricated Metal Product Manufacturing332212 | — | ◐ LIKELY ACTIVE |
| SMSpecialized Machine | Tea | SD | Machinery Manufacturing333517 | 1-19 | ◐ LIKELY ACTIVE |
| SWSupreme Welding, INC. | Clear Lake | SD | Fabricated Metal Product Manufacturing332312 | — | ◐ LIKELY ACTIVE |
| TITrail-eze INC | Corsica | SD | Transportation Equipment Manufacturing336212 | — | ◐ LIKELY ACTIVE |
| TRT & R Electric Supply Co., INC. | Colman | SD | Electrical Equipment, Appliance & Component Manufacturing335311 | — | ◐ LIKELY ACTIVE |
| TCTwin City Fan Companies LTD. | Brookings | SD | Machinery Manufacturing333413 | — | ◐ LIKELY ACTIVE |
| TCTwin City Fan LTD | Elkton | SD | Machinery Manufacturing333412 | — | ◐ LIKELY ACTIVE |
| UIUltiMed Inc. | De Smet | SD | Miscellaneous Manufacturing339112 | 20-99 | ◐ LIKELY ACTIVE |
| VIVermeer INC. | Freeman | SD | Textile Product Mills314999 | — | ◐ LIKELY ACTIVE |
| WTWilson Trailer Yankton | Yankton | SD | Machinery Manufacturing333111 | 100-499 | ◐ LIKELY ACTIVE |
| AHAmpi - Hoven | Hoven | SD | Food Manufacturing311513 | — | ◐ LIKELY ACTIVE |
| AIAstec Industries | Yankton | SD | Machinery Manufacturing333120 | — | ◐ LIKELY ACTIVE |
| CCCustom Coils INC | Alcester | SD | Electrical Equipment, Appliance & Component Manufacturing335311 | — | ◐ LIKELY ACTIVE |
Dakota Bodies, LLC | Watertown | SD | Transportation Equipment Manufacturing336211 | — | ◐ LIKELY ACTIVE |
| DPDakota Pork Industries | Mitchell | SD | Food Manufacturing311612 | — | ◐ LIKELY ACTIVE |
| EDEast Dakotas Renewable Energy, LLC | Centerville | SD | Beverage and Tobacco Product Manufacturing312140 | — | ◐ LIKELY ACTIVE |
| GPGraphic Packaging International LLC | Mitchell | SD | Paper Manufacturing322212 | — | ◐ LIKELY ACTIVE |
| HPHills Products Group - Whitewood Treating Plant | Whitewood | SD | Wood Product Manufacturing321114 | — | ◐ LIKELY ACTIVE |
| IMInfinity Machine LLC | Rapid City | SD | Fabricated Metal Product Manufacturing332710 | — | ◐ LIKELY ACTIVE |
| JEJerry's Electric, INC | Colman | SD | Computer and Electronic Product Manufacturing334416 | — | ◐ LIKELY ACTIVE |
| LEL.g. Everist, INC. - East Sioux Quarry | Sioux Falls | SD | Petroleum and Coal Products Manufacturing324121 | — | ◐ LIKELY ACTIVE |
| LELumber Exchange, LLC C/o Lloyd Companies | Sioux Falls | SD | Computer and Electronic Product Manufacturing334512 | — | ◐ LIKELY ACTIVE |
| MWMaguire Water | Sioux Falls | SD | Fabricated Metal Product Manufacturing332420 | — | ◐ LIKELY ACTIVE |
| MMMasaba Mining Equipment | Vermillion | SD | Machinery Manufacturing333131 | — | ◐ LIKELY ACTIVE |
| MRMidwest Railcar Repair INC | Brandon | SD | Transportation Equipment Manufacturing336510 | — | ◐ LIKELY ACTIVE |
| PIPersona INC. - Watertown | Watertown | SD | Miscellaneous Manufacturing339950 | — | ◐ LIKELY ACTIVE |
| PCPresidio Components, INC | Sioux Falls | SD | Computer and Electronic Product Manufacturing334416 | — | ◐ LIKELY ACTIVE |
| SESiouxland Energy Cooperative | Hudson | SD | Chemical Manufacturing325998 | — | ◐ LIKELY ACTIVE |
| SMSioux Marble, INC. | Brandon | SD | Plastics and Rubber Products Manufacturing326191 | — | ◐ LIKELY ACTIVE |
| TITrail-eze INC. | Platte | SD | Transportation Equipment Manufacturing336212 | — | ◐ LIKELY ACTIVE |
| TRT & R Service Company | Colman | SD | Electrical Equipment, Appliance & Component Manufacturing335311 | — | ◐ LIKELY ACTIVE |
| TCTwin City Fan Companies | Mitchell | SD | Machinery Manufacturing333412 | — | ◐ LIKELY ACTIVE |